甲氨蝶呤联合米非司酮治疗早期异位妊娠97例疗效观察|甲氨蝶呤异位妊娠
【摘要】 目的 探讨甲氨蝶呤联合米非司酮治疗早期异位妊娠的疗效及安全性。 方法 选取早期异位妊娠患者97例，按照随机数字表法分为观察组49例，对照组48例。对照组： 甲氨蝶呤50 mg静脉推注1次/d，连用5 d，次日用甲酰四氢叶酸钙6 mg肌内注射解毒。观察组： 甲氨蝶呤20 mg静脉推注1次/d，连用5 d；米非司酮50 mg，空腹口服，每12 h用1次，连用6次，总量300 mg。 结果 观察组治愈43例，对照组治愈34例，观察组优于对照组，有显著性差异( P 0.05)。 结论 联合应用甲氨蝶呤与米非司酮对于早期未破裂异位妊娠疗效显著，不良反应发生率低，适宜基层医疗单位推广应用。
【关键词】
甲氨蝶呤；米非司酮；异位妊娠；血β-HCG
Clinical observation of treatment by Methotrexate combined with mifepristone in 97 cases of ectopic pregnancy
LI Xiu-yun. Department of Obstetrics and Gynecology,The First People’s Hospital of Pingyuan County,Shandong 253100,China
【Abstract】 Objective
To investigate the methotrexate therapy joint mifepristone influences early ectopic pregnancy, safety and efficacy. Methods The patients with early ectopic pregnancy 97 an example, and according to the random number tables were divided into the observation group 49 cases and control 48 cases. The control group: methotrexate 50 mg intravenous qd, repeat for 5 d, and the next day the four hydrogen folic acid calcium with formex 6 mg muscle injection detoxification. The observation group: methotrexate 20 mg intravenous qd, repeat for 5 d,Get 50 mg,hollow oral, every 12 h with 1, 6 times act, and the amount of 300 mg. Results The observation group cure 43 cases and control 34 cases were cured, the observation group better than control group, significant difference ( P 0.05). Conclusion Combined application methotrexate for early mifepristone influences and unruptured ectopic pregnancy curative effect is distinct, adverse reaction rate low, appropriate application basic-level medical units.
【Key words】
Methotrexate； Mifepristone； Ectopic pregnancy； β-HCG of blood
异位妊娠是孕卵在子宫外着床发育的异常妊娠，是妇产科常见急腹症，约占妊娠总数的2%，可引起腹腔内出血甚至休克，是孕产妇的主要死亡原因之一，给妇女的生命安全及身体健康带来极大威胁，被视为具有高度危险的早期妊娠并发症［1］。随着近年来妇科炎症、人工流产、药物流产的增多，异位妊娠患病率呈逐年上升趋势，呈现年轻化［2］。随着阴道超声、血人绒毛膜促性腺激素(β-HCG)及腹腔镜技术的突破性进展，使得异位妊娠的破裂前早期确诊率进一步提高，为成功保留生育能力、保守治疗提供了客观条件。本研究应用甲氨蝶呤(MTX)联合米非司酮治疗早期异位妊娠97例，疗效满意，现报告如下。