微生态制剂、蒙脱石散剂、干扰素三联法治疗小儿秋季腹泻的临床疗效观察:蒙脱石散小儿慎用

　　[摘要] 目的 观察微生态制剂、蒙脱石散剂、干扰素三联法治疗小儿秋季腹泻的临床疗效。 方法 将84例患儿按随机数字表分为观察组42例和对照组42例，对照组口服蒙脱石散剂冲剂，肌内注射重组人干扰素，观察组在对照组基础上，口服枯草杆菌、肠球菌二联活菌多维颗粒剂（妈咪爱），2周岁者每次1～2袋、1～2次/d，3 d为1个疗程，观察治疗前后患儿症状改善情况，计算患儿症状复常时间与出院时间。 结果 （1）观察组的治愈率、总有效率分别为61.90%、95.24%，对照组的治愈率、总有效率分别为28.57%、76.19%，观察组的治愈率、总有效率均明显高于对照组，差异具有统计学意义（P ＜ 0.05）；（2）观察组的退热、大便次数复常、大便性状复常、粪便镜检复常、平均出院时间较对照组均明显缩短，各项指标差异均具有统计学意义（P ＜ 0.05）。 结论 微生态制剂、蒙脱石散剂、干扰素三联法治疗小儿秋季腹泻临床疗效确切，可双向调节肠道菌群失调，改善肠道内环境，保护、修复受损黏膜，促进消化道上皮组织再生。
　　[关键词] 微生态制剂；蒙脱石散剂；干扰素；小儿秋季腹泻；临床应用
　　[中图分类号] R975+.3 [文献标识码] A [文章编号] 1674-4721（2012）07（c）-0100-03
　　The effect observation of probiotics, montmorillonite powder and interferon in treatment of infantile autumn diarrhea
　　YE Zuowen
　　Pediatrics Department, Zijin County People"s Hospital of Heyuan City in Guangdong Province, Zijin 517400, China
　　[Abstract] Objective To observe the effect of probiotics, montmorillonite powder and interferon in the treatment of infantile autumn diarrhea. Methods Eighty-four patients were divided into observation group (42 cases) and control group (42 cases), the control group was given montmorillonite powder granules and recombinant human interferon intramuscular injection, the observation group was given bacillus subtilis, enterococcus bivalent viable multidimensional granules oral on the basis of the control group, patients with the age 2 years old were given 1-2 bags once, 1-2 times a day, both groups were treated for 3 days for a course, the symptoms were observed before and after treatment, and the symptoms recover time and discharge time were calculated. Results (1)The cure rate and the total efficiency of observation group were 61.90% and 95.24% respectively, that of the control group were 28.57% and 76.19%, the cure rate and total efficiency of the observation group was significantly higher than that of the control group, the difference was statistically significant (P < 0.05); (2)The time of fever recover, stool frequency normalization, normalization of stool consistency, stool microscopy normalization, and the average discharge time were significantly shorter than those of the control group, the differences were statistically significant (P < 0.05). Conclusion The probiotics, montmorillonite powder and interferon has exact clinical efficacy in the treatment of infantile autumn diarrhea, it can bi-directionally regulate intestinal flora, improve the intestinal environment, protect and repair damaged mucosa, promote tissue regeneration of digestive tract epithelial.