对于危重急性中毒的患者应立即进行 [复方大黄水对急性中毒患者酶学的影响]
【摘要】 目的 探讨复方大黄水治疗对中毒患者酶学的影响，明确其对中毒的治疗作用。方法 将120例各种中毒患者随机分成采用常规治疗+复方大黄水治疗的治疗组和仅采用常规治疗的对照组，每组60人，检测对比两组患者丙氨酸氨基转移酶（ALT）、谷草转氨酶（AST）、胆碱酯酶（CHE）等酶学指标的变化，记录两组患者平均住院时间。结果 两组患者治疗前ALT、AST、CHE比较差异均无统计学意义（P＞0.05），治疗后ALT、AST显著下降（P＜0.01），CHE显著上升（P＜0.01），治疗组治疗后CHE、ALT、AST三个指标的改善程度优于对照组（P＜0.01）。治疗组的住院时间显著短于对照组（P＜0.01）。结论 复方大黄水煎剂对中毒患者器官组织有保护作用，辅助治疗效果肯定。
【关键词】 复方大黄水；中毒；全身炎症反应综合征；多器官功能障碍综合征；菌群失调；毒素/细菌移位
文章编号：1003-1383(2012)04-0479-03
中图分类号：R 994.1 文献标识码：A
doi:10.3969/j.issn.1003-1383.2012.04.008
Enzymatic effect of compound rhubarb decoction on acute poisoned patients
GE Cheng, ZHANG Li
(1.Department of Emergency Medicine/EICU,2.Traditional Chinese Medicine,
The People’s Hospital of Xingyi, Xingyi 562400, Guizhou,China)
【Abstract】 Objective To observe the enzymatic effect of compound rhubarb decoction on poisoned patients and make its therapeutic effect for poisoning. undergoing ALT,AST,CHE enzyme effects.
Methods 120 cases of poisoned patients were randomly divided into the treatment group (conventional treatment and compound rhubarb decoction treatment) and the control group (conventional treatment), each with 60 patiens. ALT,AST,CHE enzyme changes of these two groups were recorded and compared. Their average hospitalization time was also recorded.
Results Before treatment,these two groups had no significant difference in ALT,AST,CHE enzyme level(P＞0.05). After treatment, compared to the control group, the ALT,AST enzyme of the treatment group decreased significantly and the CHE enzyme increased significantly(P＜0.01). The treatment group had better improvement for ALT,AST,CHE enzyme than the control group(P＜0.01).The hospitalization time of the treatment group was significantly lower than that of the control group(P＜0.01).
Conclusion Compound rhubarb decoction can protect the organ tissue of poisoned patients and play a good role in adjuvant therapy.
【Key words】 compound rhubarb decoction；poisoning；systemic inflammatory response syndrome；multiple organ dysfunction syndrome；dysbacteriosis；endotoxin/bacterial translocation
各种急性中毒是现代社会常见疾病，毒物导致机体组织器官损伤，酶学异常，引发感染、全身炎症反应综合征(systemic inflammatory response syndrome,SIRS)、多器官功能障碍综合征(multiple organ dysfunction syndrome,MODS)，增加患者致残率和死亡率。尤以有机磷农药、镇静催眠类药物对人体造成的损伤日益严重，其直接或间接引起并发症危害人类健康及生命，如不及时抢救，病死率高，治疗费用昂贵。中医中药疗法可以保护受损害器官组织，促进功能恢复，改善预后，降低治疗费用。中草药复方大黄水是一种有效、简单、方便的辅助治疗手段，费用低。我们应用常规治疗方法+复方大黄水治疗各类急性中毒患者60例，并与同期常规治疗的60例中毒患者对照，观察复方大黄水治疗对中毒患者器官功能酶学影响及临床疗效，报告如下。