蜂蜜乳腺癌相关性研究 [乳腺癌患者不同水平的Ki67表达及其相关性的临床研究]

　　【摘要】目的研究乳腺癌患者中不同增殖活性的Ki67的表达及其表达水平与乳腺癌的临床分期、淋巴结转移的相关性。方法选取已手术的乳腺癌患者67例作为研究对象，根据Ki67的水平高低分为一组、二组、三组3组，将3组中各研究对象的临床分期及淋巴结转移两项临床指标进行统计学分析，比较乳腺癌患者中不同水平的Ki67与上述两项临床指标之间的相关性。结果一组中III+IV期临床分期总和所占的百分比为133％，二组中临床分期III+IV期所占的百分比为333％，三组中临床分期III+IV期所占的百分比为667％，经统计学分析，差异具有统计学意义(P<005)。一组中经统计淋巴结转移率为167％，二组中淋巴结转移率为361％，三组中淋巴结转移率为472％，统计学分析，差异具有统计学意义(P<005)。结论随着Ki67表达水平的逐渐升高，不同乳腺癌患者的临床分期及淋巴结转移率也随之升高，说明Ki67表达水平与乳腺癌患者的临床分期及淋巴结转移率之间具有一定的相关性。
　　【关键词】Ki67；乳腺癌；相关性
　　Clinical research of different levels of Ki67 expression of breast cancer patients and its correlationHAO Pei, JIAO Yanyan, LUANG Wenge Internal Medicine of Chengyang District Peoples Hospital in Qingdao city of Shandong province,Qingdao 266109,China
　　【Abstract】ObjectiveTo study the correlation between the expression of Ki67 in breast cancer patients in different proliferative activity and its expression level and clinical stages of breast cancer, lymph node metastasis MethodsSelect operation in patients with breast cancer in 67 cases as the research object, according to the Ki67 level divided into three groups,in each group, the research object of the clinical stage and lymph node metastasis in two clinical indexes were analyzed statistically, comparison of breast cancer patients with different levels of Ki67and the two clinical indices ResultsOf a phase III+IV clinical staging of summation of the percentage of 133%, two groups of clinical stage III+IV the percentage of 333%, three groups of clinical stage III+IV the percentage of 667%, through statistical analysis, the difference was statistically significant (P<005) Group statistics by the lymph node metastasis rate was 167%, in two groups of lymph node metastasis rate was 361%, in three groups of lymph node metastasis rate was 472%, statistics analysis, difference has statistical significance (P<005) ConclusionWith the expression level of Ki67increased gradually, different breast cancer patients with the clinical staging and lymph node metastasis rate was increased, Ki67expression levels in patients with breast carcinoma clinical stage and lymph node metastasis rate has certain relation.
　　【Key words】Ki67; Breast cancer;Correlation
　　作者单位：266109山东省青岛市城阳区人民医院肿瘤内科乳腺癌是严重威胁女性健康的常见恶性肿瘤之一,西方发达国家尤为突出。有资料统计，随着乳腺癌发病率的逐渐升高，在西方国家其发病率己超过宫颈癌，成为妇女癌症死亡的主要原因。近年来,我国乳腺癌的发病率也逐年升高且发病年龄趋于年轻化［1］。
　　肿瘤的发生发展与肿瘤细胞的失控性生长、增殖和转移具有密切的关系。近年来对肿瘤标记物的研究成为热点，Ki67是人类所有增生细胞核中普遍存在的一种抗原标记物，最初的定义为标准型单克隆抗体Ki67，是细胞增殖必须的非组蛋白核蛋白，可以反应细胞增殖的状态。国内外的大量研究资料也表明［2，3］在多种常见的恶性肿瘤中其表达水平远高于相应的正常组织，因此我们采用回顾性分析的方法研究已手术的67例乳腺癌患者的Ki67表达水平及其与患者临床分期、淋巴结转移的相关性。现将研究结果汇报如下。