【雌激素受体、孕激素受体在甲状腺乳头状癌中的表达及临床意义】 雌激素受体孕激素受体

　　[摘要] 目的 探讨雌激素受体（ER）、孕激素受体（PR）在甲状腺乳头状癌、甲状腺腺瘤中表达情况。 方法 用SABC免疫组化法检测ER、PR在164例甲状腺乳头状癌、128例甲状腺腺瘤、40例正常甲状腺组织中表达情况，并分析ER、PR的表达与甲状腺乳头状癌患者性别、淋巴转移的相关性。 结果 ER、PR在甲状腺乳头状癌、甲状腺腺瘤中表达阳性率明显高于正常组织，其差异具有高度统计学意义（χ2 = 40.01、33.47，P < 0.01；χ2 = 8.19、 8.40，P < 0.01），甲状腺乳头状癌和甲状腺腺瘤ER、PR阳性表达差异具有高度统计学意义（χ2 = 24.56、16.81，P < 0.01）。甲状腺乳头状癌患者中淋巴转移者、无淋巴结转移者的ER、PR阳性表达差异具有高度统计学意义（χ2 = 18.39、8.84，P < 0.01）。结论 ER、PR参与甲状腺乳头状癌的发生、发展，检测ER、PR能对甲状腺乳头状癌的早期诊断和预后提供帮助。
　　[关键词] 雌激素受体；孕激素受体；甲状腺乳头状癌
　　[中图分类号] R736.1 [文献标识码] A [文章编号] 1673-7210（2012）07（b）-0019-02
　　Expression and clinical significance of estrogen receptor and progesterone receptor in papillary thyroid carcinoma
　　GUO Haipeng1 PENG Yuhui2 LIU Muyuan1 YANG Xihong1▲
　　1.Department of Head and Neck Surgery, the Hospital Affiliated to Shantou University Medical College, Guangdong Province, Shantou 515031, China; 2. Department of Laboratory, the Hospital Affiliated to Shantou University Medical College, Guangdong Province, Shantou 515031, China
　　[Abstract] Objective To evaluate the expression and clinical significance of estrogen receptor (ER) and progesterone receptor (PR) in papillary thyroid carcinoma and thyroid adenom. Methods Immunohistochemistry (SABC) was used to detect the expression of ER, PR in 164 cases of papillary thyroid carcinoma,128 cases of thyroid adenoma, 40 cases of normal thyroid tissue. The correlation between expression and clinical features including histological type, gender disparity and lymphatic metastasis were analyzed. Results Compared with the normal thyroid tissue, the positive rates of ER and PR were higher in papillary thyroid carcinoma and thyroid adenoma, with statistical significance (χ2 = 40.01, 33.47, P < 0.01; χ2 = 8.19, 8.40, P < 0.01). There was significant difference of ER, PR expressions between papillary thyroid carcinoma and thyroid adenoma (χ2 = 24.56, 16.81, P < 0.01). There was significant difference of ER, PR expressions between lymphatic metastasis and without lymphatic metastasis of papillary thyroid carcinoma. (χ2 = 18.39, 8.84, P < 0.01). Conclusion ER and PR both contribute to the development of papillary thyroid carcinoma.
　　[Key words] ER; PR; Papillary thyroid carcinoma
　　甲状腺肿瘤是头颈部最常发肿瘤，以甲状腺乳头状癌为最常见的甲状腺恶性肿瘤病理类型。女性发病率大于男性，以育龄期中青年女性为常见发病人群。近年研究发现，非性激素靶器官也存在性激素受体表达[1]，提示这些组织肿瘤的发生发展可能存在一定的激素依赖性，其具体机制不详。ER、PR检测在乳腺癌、前列腺癌、肺癌的治疗和预后中具有重要临床意义，而在甲状腺肿瘤中较少报道。本研究通过免疫组化检测雌激素受体（ER）、孕激素受体（PR）在甲状腺乳头状癌、甲状腺腺瘤和正常甲状腺组织中表达差异及甲状腺乳头状癌中ER、PR表达与性别、淋巴转移的相关性，初步探讨ER、PR在甲状腺乳头状癌中的临床意义。