[不同强度噪声对高血压患者肾素活性的影响]肾素活性偏高的轻度高血压患者首选
[摘要] 目的 探讨不同强度噪声对高血压患者肾素活性（PRA）的影响。 方法 选择以从事和噪音相关工作的高血压患者1 150例，检测其接触不同强度噪音后血液中的PRA。从分子生物学上研究噪音和高血压的关系和规律，揭示其原理。 结果 在接触噪音强度＜80 dB的高血压患者中，PRA的浓度半年后及1年后无明显升高（P > 0.05）；在接触噪音强度＞80 dB的高血压患者中，PRA的浓度1年后比研究前明显升高（P ＜ 0.05）；同时1年后同个强度的噪音中血压越高的患者PRA的浓度越高（P ＜ 0.05）。 结论 接触＞80 dB强度的噪音能使高血压患者的血压升高，随着噪音强度的加大，血压升高得越明显；在同个噪音强度中血压越高的患者血压升高得越明显。
[关键词] 噪声；高血压患者；肾素活性；影响
[中图分类号] R852.24 [文献标识码] A [文章编号] 1674-4721（2012）07（c）-0008-03
The influence of different strength noise on the PRA patients with hypertension
PENG Guangyi1 CHEN Jiancong1 ZHAO Xiaoling1 HUANG Long2 YANG Lvshun2 HE Qian2 KONG Guihua2
1.Fuyong Prevention of Health Station in Bao′an District of Shenzhen City in Guangdong Province, Shenzhen 518103, China; 2.Xixiang People′s Hospital of Bao′an District of Shenzhen City in Guangdong Province, Shenzhen 518102, China
[Abstract] Objective To observe the influence of different strength noise on the PRA patients with hypertension. Methods Chose 1 150 noise workers who were patients with hypertension. In different noise intensity, we were testing the PRA of in the blood. Studied the relationship and rules between noise and high blood pressure from molecular biology, revealed its principle. Results In patients with hypertension who contacted ＜80 dB noise, the concentration of the PRA had no obvious risen after six months and one year later (P > 0.05); In patients with hypertension who contacted ＞80 dB noise, the PRA of a year later was significantly higher than before the researched (P < 0.05); One year later, the PRA of the higher blood pressure patients were the higher in the same strength of noise (P < 0.05). Conclusion The blood pressure have obvious rising in patients with hypertension who contacted ＞80 dB noise. With the increase of noise intensity, it is obvious that the blood pressure have been rising. The blood pressure of the higher blood pressure patients are the higher in the same strength of noise.
[Key words] Noise; Hypertension patients; PRA; Influence
噪声是常见的职业性有害因素。动物实验和人体实验证实，噪声可导致血压暂时性升高[1]。但国内对于已患有高血压的患者在不同噪声中是否能引起血压进一步地升高未见报道，使得噪声与高血压患者的关系仍然很不明确。本课题主要是以从事和噪音相关工作的高血压患者作为研究对象，检测高血压患者血液中的肾素活性（PRA），揭示不同强度噪音和高血压患者血液中的PRA浓度的关系，从分子生物学上研究噪音和高血压的关系和规律，揭示其原理。
1 资料与方法
1.1 一般资料
选取2011年4月～2012年4月本市福永镇以从事和噪音相关工作的高血压患者1 150例，年龄30～48岁，平均（38.2±3.5）岁；其中，女工248例，占21.57%；男工902例，占78.43%。采用TES-1353积分式噪音计对车间的噪声环境进行检测，不同强度噪音的高血压患者人数为：（1）＜50 dB，203例；（2）50～80 dB，339例；（3）80～110 dB，350例；（4）110～150 dB，157例；（5）＞150 dB，101例。对所有高血压患者进行分组，（1）轻度，575例；（2）中度，339例；（3）重度，220例；（4）单纯收缩期高血压，16例。同一个噪声强度中的血压患者人数见表1。