阿托伐他汀钙片能软化血管吗【阿托伐他汀对老年高血压患者血管内皮功能及炎症因子的影响】

　　[摘要] 目的 探讨阿托伐他汀对老年高血压患者血管内皮功能的作用及抑制炎症因子的激活，以便更好地控制和治疗高血压疾病。 方法 将108例老年高血压患者自愿分为治疗组和对照组，各54例。对照组高血压患者进行常规的高血压治疗，治疗组患者在常规治疗基础上给予阿托伐他汀药物进行治疗。 结果 经过12周治疗后，常规治疗后对照组患者血脂各项指标较治疗前无太大改善，而治疗组血脂各项指标治疗后较治疗前有明显改善（P ＜ 0.05）；治疗组C-反应蛋白（CRP）、血浆纤维蛋白原定量（FIB）、非创伤性血管内皮功能与治疗前有显著差异（P ＜ 0.05），对照组治疗前后测定结果无明显差异（P ＞ 0.05）。 结论 对于老年高血压患者，在常规进行降压治疗的同时，合并使用阿托伐他汀药物可以起到调节血脂的作用，能明显改善患者血管内皮功能及抑制炎症因子。
　　[关键词] 阿托伐他汀；高血压；血管内皮功能；老年
　　[中图分类号] R544.1 [文献标识码] A [文章编号] 1673-7210（2012）07（a）-0078-02
　　The effect of Atorvastatin on vascular endothelial function and inflammatory factors of elderly patients with hypertension
　　MAI Haiyuan HUANG Zhifen ZHOU Zuyong
　　Department of Cardiology, Heshan People"s Hospital of Guangdong Province, Heshan 529700, China
　　[Abstract] Objective To study the activation of Atorvastatin on endothelial function in elderly patients with hypertension and suppression of inflammatory cytokines, in order to better control and treat hypertensive disorders. Methods 108 elderly hypertensive patients were divided into the treatment group (54 patients) and the control group (54 patients). In the control group, hypertensive patients were treated with conventional high blood pressure therapy way, and in the treatment group, patients were treated with Atorvastatin on the basis of conventional therapy. Results After 12 weeks of treatment, there weren"t many improvement serum lipid indicators in the control group than treatment before, and the treatment group after treatment lipid indicators have improved significantly (P ＜ 0.05) than before treatment; in the treatment group, C-reactive protein (CRP), plasma fibrinogen quantification (FIB) in non-traumatic vascular endothelial function before treatment were significantly different (P ＜ 0.05), in the control group measured before and after there were no significant difference (P ＞ 0.05). Conclusion For elderly patients with hypertension, in the conventional antihypertensive therapy at the same time, merging the use of Atorvastatin drugs can play a role in regulation of blood lipids, can significantly improve endothelial function in patients and suppression of inflammatory cytokines.
　　[Key words] Atorvastatin; Hypertension; Vascular endothelial function; Elderly
　　临床实践证实对高血压患者单一使用降压药物可将心血管事件的发生率下降30%左右，这说明对高血压患者进行单纯降压治疗并不能完全控制患者心血管事件的发生[1]。高血压患者在发病早期已经在体内存在内皮功能障碍，而高血压患者发生动脉粥样硬化的启动子即为内皮功能障碍[2]。因此，改善高血压患者的内皮功能能够对降低高血压患者发生心血管事件有益。研究证实，药物阿托伐他汀能有效防治患者的血管内皮功能，显著降低患者冠心病的发病率、病死率，降低患者总的死亡率[2]。本文将探讨阿托伐他汀对老年高血压患者血管内皮功能的作用及抑制炎症因子的激活，以便更好地控制和治疗高血压疾病。现报道如下：