【食管癌患者围术期血清热休克蛋白27、70、DKK-1及红细胞免疫黏附促进、抑制因子变化规律研究】食管癌血清肿瘤标记物

　　[摘要] 目的 研究食管癌患者围术期血清热休克蛋白27（HSP27）、70（HSP70）、DKK-1及红细胞免疫黏附促进因子（RFER）、抑制因子（RFIR）的变化规律。 方法 选取2009年11月～2011年11月于本院进行手术治疗的62例食管癌患者为观察组，同时选取同期62例健康体检人员为对照组，将对照组与观察组术前、术后1、5、10 d的血清HSP27、HSP70、DKK-1及RFER、RFIR水平进行对比。 结果 观察组血清HSP27、HSP70、DKK-1及RFIR水平均高于对照组，RFER低于对照组，差异有统计学意义（P < 0.05）；与术前相比，观察组术后1、5、10 d的HSP27、HSP70、DKK-1及RFIR水平持续下降，而RFER则持续上升，且术后TNM分期Ⅰ期患者因子水平优于Ⅱ、Ⅲ期患者，差异均有统计学意义（均P < 0.05）。 结论 食管癌患者围术期血清HSP27、HSP70、DKK-1及RFER、RFIR的变化规律可反映手术效果，并且对于疾病的诊断也有较为明显的价值。
　　[关键词] 食管癌；围术期；热休克蛋白27；热休克蛋白70；DKK-1；红细胞免疫黏附促进因子；红细胞免疫黏附抑制因子；变化规律
　　[中图分类号] R735.1 [文献标识码] A [文章编号] 1673-7210（2012）07（a）-0046-03
　　Study on the variation of serum HSP27, HSP70, DKK-1, RFER, RFIR in patients with esophageal carcinoma during perioperative period
　　SHANG Liqun WANG Wei LI Xuechang LIU Junqiang WEN Feng LI Jun
　　Department of Thoracic Surgery, Navy General Hospital of PLA, Beijing 100048, China
　　[Abstract] Objective To investigate the variation of serum heat shock protein 27 (HSP27), heat shock protein (HSP70), DKK-1 and RFER, RFIR in patients with esophageal carcinoma during perioperative period. Methods 62 cases of patients with esophageal carcinoma adopted surgical treatment in our hospital from November 2009 to November 2011 were selected as the observation group, at the same time 62 healthy person were selected as the control group. Then the serum HSP27, HSP70, DKK-1 and RFER, RFIR between the control group and observation group before surgery and 1, 5, 10 d after surgery were compared. Results The serum HSP27，HSP70，DKK-1 and RFER of the observation group were all higher than those of control group, RFER was lower than that of the control group, the differences were statistically significant (P < 0.05). Compared with before surgery, serum HSP27, HSP70, DKK-1 and RFER decreased continuously at 1, 5, 10 d after surgery, RFER increased continuously, and factors levels of stage Ⅰ of TNM after surgery were all better than those of stage Ⅱ and Ⅲ, the differences were statistically significant (P < 0.05). Conclusion The variation of serum HSP27, HSP70, DKK-1 and RFER, RFIR in patients with esophageal carcinoma during perioperative period can reflect the effect of surgery, and it is worthy for the diagnosis.
　　[Key words] Esophageal carcinoma; Perioperative period; HSP27; HSP70; DKK-1; RFER; RFIR; Variation
　　食管癌患者的治疗方法包括手术、化疗、放疗等，但是对于早期及中期患者效果较佳，晚期效果不理想，在其手术治疗过程中较多的机体血清因子随之发生变化，且这种变化可以反应疾病的发展，具有较高的临床价值[1]。对血清因子变化规律的研究可以了解手术的治疗效果[2]。本文笔者就食管癌患者围术期血清热休克蛋白27（HSP27）、70（HSP70）、DKK-1及红细胞免疫黏附促进因子（RFER）、抑制因子（RFIR）的变化规律进行了分析研究，以期探讨其在临床治疗中的作用，现总结报道如下：